-- Syn-AKE is a peptide known as Tripeptide-3 or Dipeptide diaminobutyroyl benzyl amide diacetate. Both of these names refer to the same peptide. Studies suggest Syn-AKE seems to be an effective synthetic peptide component that may mimic the effects of a Walgerin 1 peptide (composed of 21 amino acids in length) discovered in the venom of the Temple Viper. This poisonous snake is native to Southeast Asia.
Research suggests Syn AKE is a short synthetic peptide developed with the intent to lessen wrinkle depth. Researchers speculate that Syn-AKE may have the potential to inhibit communication between muscles and nerves, functioning like that of botulinum toxin via relaxing certain muscle groups and, as a result, diminish the appearance of wrinkles as exhibited in certain animal studies [i].
"The Syn-AKE invokes its action by reversibly blocking the muscle nAChR by blocking the ion channel," stated Pentapharm. Consequently, the Na+ uptake is significantly disrupted while the muscles relax. Research suggests Syn-AKE might help muscles relax, resulting in lessened wrinkle depth. Recently published research suggests that Syn-AKE at an early stage may help postpone the onset of wrinkles and prevent greater depth. Findings imply the peptide may slow down the passage of signals between neurons and muscles. These studies suggest that it may lessen the depth of wrinkles in only a few days. It was posited by researchers that Syn-AKE introduction twice a day for even two days might diminish the depth of wrinkles by as much as 50% within that duration. [ii]
Syn-AKE Peptide: Mechanism of Action
Studies on Syn-AKE suggest that the peptide may lower the number of muscle movements and the mobility of the cells; this helps the skin become smoother. The peptide, the synthetic version of venom, seems to temporarily relax muscles, which may even prevent the development of new wrinkles in the skin and improve the condition of present wrinkles.
The constant contraction of certain muscles may cause wrinkles and lines. The suppleness of the skin diminishes over time. As a direct consequence, it can no longer regain its initial smooth aspect. Studies suggest Syn-AKE may exhibit some potential to mitigate this decline. Researchers speculate Syn-AKE may have a cumulative impact that diminishes if not presented regularly.
Syn-AKE seems to be a competitive antagonist of acetylcholine receptors found in the muscles [iii]. To put this another way, studies suggest it may compete with acetylcholine for the ability to connect to the cholinergic receptors. One of the fundamental and most important neurotransmitters in the nervous system is acetylcholine. It utilizes this neurotransmatter to communicate between nerves and muscles. After the tension has been alleviated, the muscle responds by shortening itself. Throughout a single day, every muscle will contract several times. The skin will show apparent indications of those contractions as a consequence of both advancing age and excessive muscular contractions in certain areas. Scientists hypothesize Syn-AKE may possibly occupy the acetylcholine receptors and inhibit them from functioning normally. As a direct consequence of this, acetylcholine might never make it to its receptors. Without acetylcholine, the muscle's contract signal will not be sent. The gradual release of muscle tension causes a reversal in the outward manifestations of the skin's aging process over time. Findings imply that Syn-AKE may operate using a mechanism conceptually similar to botulinum toxin [iv]. Research suggests the antagonism of cholinergic receptors that the peptide may cause may possibly be wholly reversed.
Syn-AKE Peptide Potential
Studies have been conducted on Syn-AKE to investigate its potential properties [v]. The research "suggests that this uniquely formulated line agent was well tolerated and provided both immediate and long-term improvements in the appearance of fine and coarse wrinkles." The following is a list of the various areas of research that professionals have concentrated on to discover the full potential of the peptide:
Aging: Syn-AKE seems to have an anti-aging impact, especially when reducing the appearance of finer dermal lines. Studies suggest Syn-AKE might assist in relaxing certain muscles and contribute to the smoothing out of the skin that lies over the muscles.
Wrinkles: Wrinkles result from muscles being too contracted for a prolonged period. Research suggests that it may help to relax certain muscle groups to inhibit wrinkle depth from developing and increasing. After only four weeks of observing the action of Syn-AKE, research teams noted a significant improvement in wrinkle depth.
Syn-AKE for sale is available at Core Peptides for licensed professionals and scientists only.
References
[i] Munawar A, Ali SA, Akrem A, Betzel C. Snake Venom Peptides: Tools of Biodiscovery. Toxins (Basel). 2018;10(11):474. Published 2018 Nov 14. doi:10.3390/toxins10110474.
[ii] Zhmak, Maxim Nurgayanovich, et al. “Peptide inhibitors of nicotinic acetylcholine receptor.” U.S. Patent No. 9,550,808. 24 Jan. 2017.
[iii] Balaev, A. N., K. A. Okhmanovich, and V. N. Osipov. “A shortened, protecting group free, synthesis of the anti-wrinkle venom analogue Syn-Ake® exploiting an optimized Hofmann-type rearrangement.” Tetrahedron Letters 55.42 (2014): 5745-5747.
[iv] Chhipa, Nadim MR, and B. Chaudhari. “Toxin as a Medicine.” Journal of Current Pharmaceutical Research 9.1 (2012): 11-8.
[v] Trookman, Nathan S., et al. “Immediate and long-term clinical benefits of a topical treatment for facial lines and wrinkles.” The Journal of clinical and aesthetic dermatology 2.3 (2009): 38.
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Organization: Core Peptides
Address: 701 E. Santa Clara St. Ventura CA 93001
Website: https://www.corepeptides.com/
Release ID: 89113470
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