Oligonucleotide Synthesis Market Will Reach USD 3.9 Million by 2025: Meticulous Research®

Oligonucleotide Synthesis Market by Product and Service (Synthesizer, Custom Oligonucleotide Synthesis Service, Probes, Primers, Linkers and Adaptor, Reagents and Consumables), Application (Research, Therapeutics, Diagnostics), and End User - Global Forecast to 2025

Over the years, the exponential growth in the field of genomics and technological advancements in biotechnology have created tremendous potential for synthetic biology to transform medicine and biomedical research. In recent past, synthetic biology start-ups are gaining greater traction with growing interest from investors and venture capitalists. According to the advocacy organization Synbiobeta, synthetic biology companies in the U.S. raised about $200 million in capital investment in 2009. This figure grew exponentially to $1.8 billion in 2017 and $3 billion in 2018.

In July 2018, Evonetix secured $1.75 million in funding from Innovate UK for its novel approach to DNA synthesis aimed at producing DNA at scale for use in synthetic biology applications. The funding will help the company to develop the enzymatic oligonucleotide synthesis method, which operates under milder aqueous conditions than phosphoramidite chemistry – the current method of choice for DNA oligonucleotide manufacturing. In January 2018, Evonetix also raised a Series A funding of a $12.3 million from Silicon Valley investor DCVC and London-based Draper Esprit to advance the development of its technology. Moreover, in September 2017, DNA Script raised $13 million (€11 million) in series A financing led by Illumina Ventures to advance development of its DNA synthesis technology. This funding helped DNA Script to strengthen its unique enzymatic technology and nucleotide chemistry platform in order to manufacture high quality oligonucleotides at faster rates and make them more affordable than the current market standards. Such investments and funding for genomic and DNA synthesis technologies is helping players to further enhance the oligonucleotide synthesis methods and increase their adoption. Meticulous Research® in its latest publication on Oligonucleotide Synthesis market states that the global oligonucleotide synthesis market is expected to grow at a CAGR of 10.4% from 2019 to 2025 to reach $3.9 billion by 2025.

The growth in oligonucleotide synthesis market is mainly attributed to the growing adoption of synthesized oligonucleotides in diagnostic and clinical applications, rising R&D expenditure and investments from governments and pharmaceutical and biotechnology companies, plummeting cost of sequencing, increasing public and private spending on genomics, and rising venture capital investments/funding. However, factors such as lack of regulations for therapeutic oligos and price erosion of synthesized oligonucleotides are likely to hinder the market growth. In addition, the difficulty in large scale synthesis of oligonucleotides and delivery of oligonucleotide drugs to specific target are recognized as major hurdles to overcome.

To provide efficient analysis, Meticulous Research® has segmented this market by product & services [synthesized oligonucleotide (primers, probes, and linkers & adapters), oligonucleotide synthesis product (reagents & consumables, equipment), custom oligonucleotide synthesis services (Intermediate scale, large scale, and small scale oligonucleotides)], by application (research, diagnostics, and therapeutics), by End User (pharmaceutical and biotechnology companies, academic research institutes, diagnostic laboratories, and others) and by geography (North America, Europe, Asia-Pacific, Latin America, and Middle East & Africa).

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Geographic Review:

Geographically, North America commanded the largest share of the global oligonucleotide synthesis market in 2018, closely followed by the Europe and Asia-Pacific regions. However, Asia-Pacific region is slated to register fastest growth during the forecast period, primarily due to growing availability of synthesized oligonucleotides, strong presence of pharma & biotech companies, growing clinical research and trial outsourcing to CROs in the region, and increase in R&D funding and activities in the APAC region.

Key Players:

The report provides competitive intelligence in terms of financials, growth strategies, product portfolios, and geographical presence on some of the key players in this market including Integrated DNA Technologies, Inc. (U.S.) (Part of Danaher Corporation), Merck KGaA (Germany), Eurofins Scientific SE (Luxembourg), Thermo Fisher Scientific Inc. (U.S.), Agilent Technologies, Inc. (U.S.), GE Healthcare (U.S.), GeneDesign, Inc. (Japan) (Part of Ajinomoto Co., Inc.), Kaneka Eurogentec (Belgium) (Part of Kaneka Corporation), LGC Biosearch Technologies (U.S.), Bio-synthesis Inc. (U.S.), TriLink BioTechnologies, LLC (U.S.) (Part of Maravai LifeSciences), and ATDBio Ltd. (U.K.), among others.
Oligonucleotide Synthesis Market by Product and Service (Synthesizer, Custom Oligonucleotide Synthesis Service, Probes, Primers, Linkers and Adaptor, Reagents and Consumables), Application (Research, Therapeutics, Diagnostics), and End User - Global Forecast to 2025

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Key Topics Covered in This Report:

1. Introduction
1.1. Market Ecosystem
1.2. Currency & Limitation
1.2.1. Currency
1.2.2. Limitations
1.3. Key Stakeholders

2. Research Methodology
2.1. Research Process
2.1.1. Secondary Research
2.1.3. Market Size Estimation

3. Executive Summary
4. Market Insights
4.1. Introduction
4.2. Market Dynamics
4.2.1. Drivers Growing Adoption of Synthesized Oligonucleotides in Diagnostics and Clinical Applications Rising R&D Expenditure and Government Investment in Pharmaceutical and Biotechnology Companies Plummeting Cost of Sequencing Increasing Public-Private Spending on Genomics Rising Venture Capital Investments/Funding
4.2.2. Restraints Lack of Regulations for Therapeutic Oligos Price Erosion of Synthesized Oligonucleotides
4.2.3. Opportunities Emerging Asian Markets Therapeutic Oligos
4.2.4. Challenges Large-Scale Synthesis of Oligonucleotides Delivery of Oligonucleotide Drugs to Specific Targets

5. Oligonucleotide Synthesis Market, by Product & Services
5.1. Introduction
5.2. Oligonucleotide Synthesis Products
5.2.1. Oligonucleotide Synthesis Equipment (Synthesizers)
5.2.2. Oligonucleotide Synthesis Reagents & Consumables
5.3. Synthesized Oligonucleotides (Pre-Designed Oligonucleotides)
5.3.1. Primers
5.3.2. Probes
5.3.3. Linkers & Adaptors
5.4. Custom Oligonucleotide Synthesis Services (Custom Oligonucleotides)
5.4.1. Large-Scale Oligonucleotide Synthesis
5.4.2. Intermediate-Scale Oligonucleotide Synthesis
5.4.3. Small-Scale Oligonucleotide Synthesis

6. Oligonucleotide Synthesis Market, by Application
6.1. Introduction
6.2. Research
6.2.1. PCR
6.2.2. qPCR/RTqPCR
6.2.3. Sequencing
6.2.4. Gene Synthesis
6.2.5. Other Research Applications
6.3. Diagnostics
6.4. Therapeutics
6.4.1. RNAi Oligonucleotide-based Therapies
6.4.2. DNA/Antisense Oligonucleotide-based Therapies
6.4.3. Immunotherapy (CpG Oligonucleotide-based Therapies)
6.4.4. Nucleic Acid Aptamers

7. Oligonucleotide Synthesis Market, by End User
7.1. Introduction
7.2. Pharmaceutical and Biotechnology Companies
7.3. Academic Research Institutes
7.4. Diagnostic Laboratories
7.5. Others

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