-- Creative Biogene, one of the leaders in microbial-based biotechnology solutions, today announced the launch of its innovative Programmable Delivery System Construction Service. This service leverages sophisticated bioengineering to repurpose bacterial contractile injection systems and Photorhabdus virulence cassette with designing, expressing, and testing for the targeted delivery of therapeutic and research payloads directly into cells.
This cutting-edge service solves one of the major challenges in medicine and molecular biology: delivering large biomolecules, such as folded proteins, base editors, and ribonucleoproteins (RNPs), into specific target cells with high efficiency and minimal off-target effects.
The core of Creative Biogene Programmable Delivery System Construction service is powered up by two advanced platforms:
Extracellular Contractile Injection Systems (eCISs): Creative Biogene utilizes these macromolecular complexes, which function like the tail of a bacteriophage, in order to physically inject payloads. Once recognizing a target cell, the system's sheath contracts and delivers its cargo directly into the cytoplasm through the cell membrane.
Photorhabdus Virulence Cassette (PVC) System: Creative Biogene employs advanced techniques that have been successfully engineered to deliver diverse cargo into human cells, which allows for the loading of complex payloads, including Cas9 proteins and ssDNA, and reprogramming the system to bind to specific receptors on human cells.
"The precision of these bacterial injection systems represents a paradigm shift for drug delivery. What we are focusing on is essentially reprogramming original, highly efficient delivery machines currently," said Marcia Brady, the marketing director at Creative Biogene. "Our professionals can support customizing these “nanosyringes” to seek out a specific cell type—such as a cancer cell—and inject a potent therapeutic protein or gene-editing tool opens up a remarkable new frontier for targeted therapies. Our comprehensive service supports clients through the entire development pipeline, from initial experimental design and vector construction to in vitro production, quality control, and validation at both cellular and animal levels."
Creative Biogene has realized significant potential applications of this technology across multiple fields. In the gene therapy field, it offers a direct route for delivering complex gene-editing tools, such as Cas9/RNP complexes, for precise genome modification. For oncology, the systems can be programmed to specifically target cancer cells and inject potent toxins or pro-apoptotic proteins. Furthermore, it provides novel methods for biocontrol, allowing researchers to modulate cellular behavior in research settings with high specificity.
Creative Biogene aims to advance the development of next-generation biologics by providing researchers and pharmaceutical developers with access to this powerful and highly adaptable delivery platform. Our professionals work to unlock new possibilities in targeted medicine and cellular engineering, overcoming long-standing delivery challenges.
About Creative Biogene
Creative Biogene is one of the biotechnology companies specializing in microbial genome editing, strain development, and biomanufacturing. With a state-of-the-art research facility and a team of expert scientists, Creative Biogene provides innovative solutions and services to researchers in the academic, pharmaceutical, and industrial sectors worldwide.
Contact Info:
Name: Marcia Brady
Email: Send Email
Organization: Creative Biogene
Address: Shirley, NY 11967, USA
Phone: 6313868241
Website: https://www.creative-biogene.com/
Release ID: 89177263
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