Creative Bioarray, one of the world’s leading biotechnology products and services provider based in US, focusing on developing unique technologies and related services to accelerate life sciences research, solve complex analytical challenges and increase laboratory productivity. Recently, Creative Bioarray announced the release of several types of cardiac cells to support grug screening and disease modeling ect. —
The cardiac system is composed of endothelial cells, muscle cells, smooth muscle cells and fibroblasts, which work together to maintain the function of the circulatory system. Abnormal cell proliferation and regulation in the cardiac system may lead to the development of cardiovascular disease. The available human cardiac cells offered by Creative Bioarray include as follows:
Human cardiac fibroblasts (CF) are the most common cell type in the heart. CF plays an important role in maintaining the extracellular matrix of the normal heart and synthesizing growth factors and cytokines. Under pathophysiological conditions, CF is involved in cardiac hypertrophy, cardiac fibrosis and scar formation after myocardial infarction. Therefore, CF represents an attractive treatment candidate for heart disease. CF culture has been widely used as a model to study the remodeling of the heart matrix by physiological (exercise) and pathological (hypertension) stressors.
Human cardiomyocytes are the most active energy cells in the human body. They are highly specialized cells with high oxygen content and contain large numbers of mitochondria. They account for up to 75% of the heart's mass. All cardiomyocytes can spontaneously depolarize and repolarize their membrane rhythmically. The contraction of cardiomyocytes is myogenic, which is independent of nerve stimulation. There is a complex signal network in cardiac myocytes, which can regulate the rhythmic pumping of the heart. A better understanding of the cardiac signaling network will help reveal the cellular mechanisms that regulate the death of cardiac myocytes. For most cardiac microphysiological systems, the ideal cell type is primary human adult cardiomyocytes.
Human cardiac microvascular endothelial cells (HCMEC) interact strongly with cardiomyocytes and therefore have a characteristic phenotype different from other microvascular endothelial cells. HCMEC regulates vascular tone by releasing and degrading endothelium-derived vasoactive factors and regulating the local levels of vasoconstrictors and vasodilators through its enzymatic activity. Many of these substances can also change the contraction behavior of the heart muscle. In addition, the microvasculature has been shown to participate in the regulation of leukocyte recruitment, inflammation and angiogenesis. They are also able to transdifferentiate into myofibroblasts, suggesting a role in the abnormal accumulation of matrix and fibrotic diseases.
“Creative Bioarray optimizes the separation, purification, subculture and growth of cardiac cells. The cells we provide ensure purity, low throughput, stringent characterization and quality control.” said Hannah Cole, the marketing director of Creative Bioarray, also added, “Our team is capable to develop and perform flexible custom-designed experiments that meet your unique needs and goals.”
About Creative Bioarray
Founded in 2005, Creative Bioarray is dedicated to offering customers innovative biotechnology products and services for research use to greatly enhance and drive innovation and standards in science. As a well-recognized industry leader with more than 10 years of experience and in-house experts supported, Creative Bioarray has already countenanced research all around the world.
Release ID: 88996509