The emergence of next-generation antibody therapeutics represented by bispeciﬁc antibodies (bsAbs) has re-shaped the antibody market landscape. Although the bsAb market is still emerging, it is developing fast and has already formed a diversified pipeline with promising therapeutic potential in the treatment of various diseases. —
Empowered by leading technology and years of experience in biomedical science, Creative Biolabs now offers an optimized inventory of customized bispecific antibody (BsAb) products. Based on the state-of-the-art strategies, different formats of BsAbs can be developed with adapted valency, structure, half-life, biodistribution, etc.
Compared with other CD3-bispecific or IgG antibodies, tandem scFv has more than thousands of times of efficiency in lysing tumor cell, which makes it one of the most important T cell recruiters for cancer treatment and immune regulation.
Featured bsAb targets include Ad fiber knob & CEA, BCMA & CD3, CD20 & CD47, doxorubicin & EGFR, FGF2 & VEGF, HER1 & HER3, PD1 & TIM-3, and TG & TPO.
Creative Biolabs is also dedicated to helping develop unique tandem scFv and also providing custom tandem scFv products linking two or more scFvs against hot targets.
Diabodies formed by incorporating heavy-chain variable fragments (VH) and light-chain variable fragments (VL) are among the smallest bsAbs. Similar to tandem scFv, diabody has a short half-life and better tissue penetration.
Featured products include albumin & IL-6R, BAFF & B7RP1, DR5 & FAP, EGFR & ZnO, FGFR1 & KLB, NGF & TNF, OPN & VEGF, and Ang2 & VEGFA.
With the well-established diabody generation platform, Creative Biolabs is also skillful at developing unique diabody, including TandAb, single-chain diabody, and diabody-Fc.
Other formats of bsAbs cover CrossMab, IgG-IgG, TandAb, Single-chain Triplebody, Minibody, Bibody, etc.
“After experiencing the development from concept to clinical trials, and from advanced design limited by the times to so many bsAbs rapidly approved, scientists around the world are accelerating the development. Continued enthusiasm will quickly further promote the development of the bsAb industry at home and abroad. And we are definitely trustworthy partners in this field.” as introduced by a senior scientist at Creative Biolabs.
More information about bsAb products and services can be found at https://www.creative-biolabs.com/bsab/.
About Creative Biolabs
Over the past 15 years, Creative Biolabs has grown into a recognized world leader in antibody discovery, engineering, production, and analysis. The bispecific antibody (bsAb) team has a collective of experienced scientists committed to providing high-quality services to customers all over the world, covering bsAb design, purification, engineering, manufacturing and bsAb analysis service. With the cutting-edge platforms and methods, a comprehensive list of BsAb products is also available to customers in academia and industry fields.
Release ID: 88993626