-- As pseudouridine and its derivatives can play an important role in a variety of biological processes, BOC Sciences, a leading supplier of pseudouridine with the largest production capacity in the world, recently announced that it can provide high-quality, competitively priced GMP and non-GMP-grade pseudouridine and its derivatives to support R&D and production.
Pseudouridine
RNA is an important molecule in the human body, which can analyze genetic information in human cells. Many RNAs in nature have undergone post-transcriptional modifications. Post-transcriptional modification plays an important role in the structure, function and metabolism of RNA. Pseudouridine is the first and most abundant RNA modification to be discovered and is called the "fifth" nucleoside. Pseudouridine modification is catalyzed by pseudouridine synthase, and is commonly found on non-coding RNAs with high abundance in cells such as tRNA, rRNA, and snRNA, and has recently been found to be present on mRNA.
Pseudouridine is the 5-position isomer of uridine, which has different characteristics from other bases and can stabilize many RNA structures. Pseudouridine modification can regulate the RNA function of specific RNA species. For example, pseudouridine in rRNA can affect the folding of rRNA, the function of ribosomes, and maintain the structure of rRNA. Pseudouridine in snRNA plays an important role in snRNP formation, spliceosome assembly and pre-mRNA. Pseudouridine in tRNA can affect the local structure of the domain where it is distributed, thereby affecting decoding activity, improving the accuracy of translation, and helping to maintain a proper reading frame. Pseudouridine in mRNA can affect mRNA splicing, stability and translation rate.
Pseudouridine derivatives
In addition to the most common pseudouridine, pseudouridine derivatives also play an important role in biological processes. Similar to pseudouridine, pseudouridine derivatives can also replace uridine in RNA for RNA modification. For example, N1-methylpseudouridine, a methylpseudouridine, can enhance the stability of RNA in biological applications such as gene silencing. N1-methylpseudouridine in mRNA enhances the translation efficiency of mRNA by increasing the density of ribosomes. N1-methylpseudouridine-modified mRNA can enhance protein expression and reduce the immunogenicity of mRNA, and it has a superior effect than the mRNA incorporated with pseudouridine.
For more information about pseudouridine and its derivatives, please visit the website: https://www.bocsci.com/pseudouridine-and-its-derivatives.html.
About BOC Sciences
BOC Sciences has professional experts, focusing on research in various fields such as pharmaceuticals, chemistry and life sciences, and provides high-quality products and services for scientists and researchers in academia and industry around the world. BOC Sciences has become the world's leading supplier of pseudouridine with the largest production capacity. The annual output of pseudouridine exceeds 500 kg. In addition to pseudouridine, BOC Sciences also provides pseudouridine derivatives to support R&D and production. All BOC Sciences products are produced in dedicated clean room equipment and undergo rigorous QC and HPLC purification to eliminate potential contamination and ensure stability, repeatability and safety between batches. Relying on the GMP synthesis platform and rich development and synthesis experience, BOC Sciences is committed to providing pseudouridine products with competitive prices and on-time delivery, and to ensure recognized quality.
Contact Info:
Name: Alex Brown
Email: Send Email
Organization: BOC Sciences
Website: https://www.bocsci.com
Release ID: 89031437
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