Hemophilia is a condition that most of the time is inherited, although it can be acquired too.
Hemophilia is a bleeding disorder that links to the X chromosome in females. Therefore, very often, females carry the disease while males suffer from it.
Furthermore, the problem with this disease is that it lacks a coagulation factor, either coagulation factor VIII (FVIII) or factor IX (FIX). The lack of the former factor, and the latter, would account for hemophilia A and hemophilia B, correspondingly. It is important to note that the factor deficiency is the result of mutations in the respective clotting factor genes.
However, this disease could develop too, without any gene involvement on the table. There could be proteins that directly attack the specific clot factor; hence, it will similarly cause a scenario in which these factors are lacking, and bleeding starts to occur. This latter outline is rare, but also a possibility.
These factors are an essential piece among a big chain reaction that allows clots to be formed.
Firstly, when there is an injury or a gap in a vessel, a cell called “platelet” will form a stopper that halts blood from continue to leak out. Secondly, several clotting factors will trigger a chain reaction that is essential for clot formation.
Moreover, this process will end up on more regulation of elements that ends in a steady and durable clot. Importantly, there are reactions in the body, which their only purpose is to stop clot formation for not to surpass the only necessary growth. And, finally, after healing, there will be clot dissolution in the long run when the job is done.
This situation is necessary and lifesaver. It helps in every cut or including significant injuries like traumatisms. The blood leakage within the body could either cause complications in the short or long run. The former, in a big blood leak, could cause hypotension or compromise essential structures like the brain. On the other hand, in the long run, someone that is permanently losing blood could develop anemia, amongst other complications—besides, the blood when somewhere else rather than the blood vessel is irritant for the body. Therefore, preventing blood leaking is essential for body well-functioning.
Hemophilia is not that common, though.
The estimation is that hemophilia affects one in every 10,000 births. Additionally, worldwide, surveys indicate an estimate of 400,000 people living with this condition.
Hemophilia A is way more common than its B homologous. The former represents 80% to 85% of all the hemophilia population.
It is important to note that, even though very often, the male suffers from the disease due to their maternal side. There is an active possibility of gene mutation, so up to one-third of the cases will happen without any prior family history.
Early diagnosis is essential for management and avoiding complications.
It will depend on the factor that is lacking the specific diagnosis and treatment of this disease. However, the manifestations of both hemophilias are otherwise the same. They tend to overlap because both of them, in the end, have a deficiency of clot formation. Hence, there will be bleeding in particular forms that a person with these factors available would not have.
This tool could be very beneficial for somebody experiencing strange bleedings.
It is a hemophilia symptoms checker. It will help to determine how likely it is for someone to have this condition. This tool is free, and it would only take a few minutes to complete it.
Originally published at https://symptoms.care on July 3, 2020.
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